Title: PDF.js viewer Author: cbfernan Created Date: 9/7/2020 8:42:59 PM INORGANIC ELEMENTS IN THE CHEMISTRY OF LIFE Wolfgang KaiM bRigitte sCHWedeRsKi axel Klein inoRganiC CHeMistRy a Wiley textbooK seRies. Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life. Professor Dr. Axel Klein, Universitaet zu Koeln, Institut fuer Anorganische Chemie, GermanyAxel Klein is a Professor of Inorganic Chemistry at the University of Cologne, Germany. Metals in Photosynthesis 7. Download Product Flyer is to download PDF in new tab. Please try again. The second edition of this classic text has been fully revised and updated to include new structure information, emerging developments in the field, and an increased focus on medical applications of inorganic compounds. The field of Bioinorganic Chemistry has grown significantly in recent years; now one of the major sub-disciplines of Inorganic Chemistry, it has also pervaded other areas of the life sciences due to its highly interdisciplinary nature. %%EOF Download Product Flyer is to download PDF in new tab. They are NOT HOSTED on our Servers. To calculate the overall star rating and percentage breakdown by star, we don’t use a simple average. The second edition of this classic text has been fully revised and updated to include new structure information, emerging developments in the field, and an increased focus on medical applications of inorganic compounds. We work hard to protect your security and privacy. His research interests lie in the preparation and investigation of novel coordination compounds including organometallic derivatives, aiming at the rational design, preparation and use of coordination units with specific properties in mononuclear or oligonuclear complexes or as part of materials. Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life. Dr Brigitte Schwederski, Institute of Inorganic Chemistry, University of Stuttgart, GermanyBrigitte Schwederski was born in 1959 in Recklinghausen, Germany. LEGAL NOTICE: The following PDFs files has been found on the Web. 10 0 obj <> endobj 231, 12 Zinc: Structural and Gene-regulatory Functions and the Enzymatic Catalysis of Hydrolysis and Condensation Reactions 235, 12.3 Carboxypeptidase A and Other Hydrolases 243, 12.4 Catalysis of Condensation Reactions by Zinc-containing Enzymes 248, 12.5 Alcohol Dehydrogenase and Related Enzymes  249, 12.6 The “Zinc Finger” and Other Gene-regulatory Zinc Proteins 251, 12.7 Insulin, hGH, Metallothionein and DNA Repair Systems as Zinc-containing Proteins 253, 13 Unequally Distributed Electrolytes: Function and Transport of Alkali and Alkaline Earth Metal Cations 257, 13.1 Characterization and Biological Roles of K+, Na+, Ca2+ and Mg2+ 257, Insertion: Heteroatom Nuclear Magnetic Resonance 262, 13.2 Complexes of Alkali and Alkaline Earth Metal Ions with Macrocycles 264, 14 Catalysis and Regulation of Bioenergetic Processes by the Alkaline Earth Metal Ions Mg2+ and Ca2+ 277, 14.1 Magnesium: Catalysis of Phosphate Transfer by Divalent Ions 277, 14.2 The Ubiquitous Regulatory Role of Ca2+ 283, 15 Biomineralization: The Controlled Assembly of “Advanced Materials” in Biology 295, 15.3.1 Calcium Phosphate in the Bones of Vertebrates and the Global P Cycle 301, 15.3.2 Calcium Carbonate and the Global Inorganic C Cycle  306, Insertion: The Global C Cycle and the Marine Inorganic C Cycle 307, 16 Biological Functions of the Nonmetallic Inorganic Elements 315, 16.4 Arsenic and Trivalent Phosphorus 316, 17 The Bioinorganic Chemistry of the Quintessentially Toxic Metals 327, 18 Biochemical Behavior of Radionuclides and Medical Imaging Using Inorganic Compounds 349, 18.1 Radiation Risks and Medical Benefits from Natural and Synthetic Radionuclides 349, 18.1.1 The Biochemical Impact of Ionizing Radiation from Radioactive Isotopes 349, 18.1.2 Natural and Synthetic Radioisotopes 350, 18.1.3 Bioinorganic Chemistry of Radionuclides 351, Insertion: Fukushima Daiichi, Chernobyl, Hiroshima and Nuclear Weapons Testing 353, 18.1.5 Technetium: A “Synthetic Bioinorganic Element” 359, 18.1.6 Radiotracers for the Investigation of the Metallome 362, 18.2 Medical Imaging Based on Nonradioactive Inorganic Compounds 362, 19 Chemotherapy Involving Nonessential Elements 369, 19.2 Platinum Complexes in Cancer Therapy 369, 19.2.1 Discovery, Application and Structure–Effect Relationships 369, 19.3 New Anticancer Drugs Based on Transition Metal Complexes 378, 19.3.1 Overview and Aims for Drug Development 378, 19.4 Further Inorganic Compounds in (Noncancer) Chemotherapy 383, 19.4.1 Gold-containing Drugs Used in the Therapy of Rheumatoid Arthritis 383, 19.4.2 Lithium in Psychopharmacologic Drugs 384, 19.4.3 Bismuth Compounds against Ulcers 385, 19.4.4 Vanadium-containing Insulin Mimetics and V-containing Anti-HIV Drugs 386, 19.5 Bioorganometallic Chemistry of Nonessential Elements 387, Phone: +4472070973841 Email: info@collegelearners.com, Uptake, transport, and storage of essential elements, Biological functions of molybdenum, tungsten, vanadium and chromium, Function and transport of alkaline and alkaline earth metal cations, Biological functions of the non-metallic inorganic elements, Biochemical behavior of radionuclides and medical imaging using inorganic compounds, Chemotherapy involving non-essential elements. Bring your club to Amazon Book Clubs, start a new book club and invite your friends to join, or find a club that’s right for you for free. 24 0 obj <>/Filter/FlateDecode/ID[<1465C645546A0E8C7983A19B5361361B>]/Index[10 19]/Info 9 0 R/Length 87/Prev 496427/Root 11 0 R/Size 29/Type/XRef/W[1 3 1]>>stream Please try your request again later. (1983). endstream endobj startxref H��W[�� ��Ux�H�L�+�w�%4�I��I�j�W����e�yT��?���u��G��"��o�*[-�ܯs��_�KRu/:W�~�����?X���߷�?�����n��{����1��� �mn��#����x�rG��9��H���D��B�4Pk��!�eյ|��g~g���+��~$4P\ �|=>��ݒ����o��[/�X�mK���m��\w��o[�_qH����a���7(����|ăٶ������CI��>Snǫ$�g84M��J�u�t�IW��}�emnr��F�{�ϟ��_GSm�w�9��ZF~����]�k�8���P4`터���e��ji��v��>a �|�ᶅzV���a� �>�5K� �-�.���"�C*}��+�`߬�JP����{M�k�%�3aJnI�|=�. Request permission to reuse content from this site, 1 Historical Background, Current Relevance and Perspectives 1, 2.1 Occurrence and Availability of Inorganic Elements in Organisms 7, Insertion: “Hard” and “Soft” Coordination Centers 14, 2.2 Biological Functions of Inorganic Elements 14, 2.3.1 Coordination by Proteins: Comments on Enzymatic Catalysis 17, Insertion: The “Entatic State” in Enzymatic Catalysis 20, 2.3.2 Tetrapyrrole Ligands and Other Macrocycles 22, Insertion: Electron Spin States in Transition Metal Ions  28, 2.3.3 Nucleobases, Nucleotides and Nucleic Acids (RNA, DNA) as Ligands 31, 3 Cobalamins, Including Vitamin and Coenzyme B12 37, 3.1 History and Structural Characterization 37, 3.2 General Reactions of Alkylcobalamins 41, 3.2.1 One-electron Reduction and Oxidation 41, Insertion: Electron Paramagnetic Resonance I 43, 3.3.1 Adenosylcobalamin (AdoCbl)-dependent Isomerases 45, 3.3.2 Alkylation Reactions of Methylcobalamin (MeCbl)-dependent Alkyl Transferases 51, 3.4 Model Systems and the Enzymatic Activation of the Co–C Bond 52, 4 Metals at the Center of Photosynthesis: Magnesium and Manganese 57, 4.1 Volume and Efficiency of Photosynthesis 57, 4.2 Primary Processes in Photosynthesis 59, 4.2.1 Light Absorption (Energy Acquisition) 59, 4.2.2 Exciton Transport (Directed Energy Transfer) 59, 4.2.3 Charge Separation and Electron Transport 62, Insertion: Structure Determination by X-ray Diffraction 62, 4.3 Manganese-catalyzed Oxidation of Water to O2 68, 5 The Dioxygen Molecule, O2: Uptake, Transport and Storage of an Inorganic Natural Product 77, 5.1 Molecular and Chemical Properties of Dioxygen, O2 77, 5.2 Oxygen Transport and Storage through Hemoglobin and Myoglobin 82, 5.3 Alternative Oxygen Transport in Some Lower Animals: Hemerythrin and Hemocyanin 92, Insertion: Resonance Raman Spectroscopy 93, 6 Catalysis through Hemoproteins: Electron Transfer, Oxygen Activation and Metabolism of Inorganic Intermediates  99, 6.2 Cytochrome P-450: Oxygen Transfer from O2 to Nonactivated Substrates 103, 6.3 Peroxidases: Detoxification and Utilization of Doubly Reduced Dioxygen 108, 6.4 Controlling the Reaction Mechanism of the Oxyheme Group: Generation and Function of Organic Free Radicals  110, 6.5 Hemoproteins in the Catalytic Transformation of Partially Reduced Nitrogen and Sulfur Compounds 112, 7 Iron–Sulfur and Other Non-heme Iron Proteins 117, 7.1 Biological Relevance of the Element Combination Iron–Sulfur 117, Insertion: Extremophiles and Bioinorganic Chemistry 118, 7.4 Polynuclear Fe/S Clusters: Relevance of the Protein Environment and Catalytic Activity 123, 7.6 Iron-containing Enzymes without Porphyrin or Sulfide Ligands 130, 7.6.1 Iron-containing Ribonucleotide Reductase 130, 7.6.3 Purple Acid Phosphatases (Fe/Fe and Fe/Zn) 133, 7.6.4 Mononuclear Non-heme Iron Enzymes 133, 8 Uptake, Transport and Storage of an Essential Element, as Exemplified by Iron 139, 8.1 The Problem of Iron Mobilization: Oxidation States, Solubility and Medical Relevance 140, 8.2 Siderophores: Iron Uptake by Microorganisms 141, Insertion: Optical Isomerism in Octahedral Complexes 144, 8.3 Phytosiderophores: Iron Uptake by Plants 149, 9 Nickel-containing Enzymes: The Remarkable Career of a Long-overlooked Biometal 163, 9.4 CO Dehydrogenase = CO Oxidoreductase = Acetyl-CoA Synthase 169, 9.5 Methyl-coenzyme M Reductase (Including the F430 Cofactor) 172, Insertion: Natural and Artificial (Industrial) C1 Chemistry 174, Insertion: Bioorganometallics II: The Organometallic Chemistry of Cobalt and Nickel 176, 10 Copper-containing Proteins: An Alternative to Biological Iron 183, Insertion: Electron Paramagnetic Resonance II 187, 10.2 Type 2 and Type 3 Copper Centers in O2-activating Proteins: Oxygen Transport and Oxygenation 191, 10.3 Copper Proteins as Oxidases/Reductases 195, 10.5 Cu,Zn- and Other Superoxide Dismutases: Substrate-specific Antioxidants 203, 11 Biological Functions of the “Early” Transition Metals: Molybdenum, Tungsten, Vanadium and Chromium  211, 11.1 Oxygen Transfer through Tungsten- and Molybdenum-containing Enzymes 211, 11.1.2 Oxotransferase Enzymes Containing the Molybdopterin or Tungstopterin Cofactor  213, 11.2 Metalloenzymes in the Biological Nitrogen Cycle: Molybdenum-dependent Nitrogen Fixation  219, 11.4 Biological Vanadium Outside of Nitrogenases 229, 11.5 Chromium(III) in the Metabolism?